Hiroshi Mitsumoto, MD, D.Sc., has been the Wesley J. Howe Professor of Neurology at Columbia University Medical Center since 1999 and the Director Emeritus (since 2019) of the MDA/ALS Clinical Research Center.  In 1968, he graduated at the top of his class from Toho University School of Medicine, Tokyo. From 1972, he pursued further medical and neurology training at Johns Hopkins University, Case Western Reserve University, Cleveland Clinic, and Tufts University. In 1983, he established the ALS Clinic at Cleveland Clinic, one of the first such multidisciplinary ALS Clinics in the country and began working at the Cleveland Clinic as the Director of the Neuromuscular Section and ALS Center. He has since been involved with extensive research in ALS, including improving patient care/management and end of life issues, multiple clinical trials, biomarker development, and multisite epidemiological studies.  He organized several large national and international ALS Conferences and is currently updating and developing the new International ALS Clinical Trial Guidelines. He was a member of Steering Committee of several clinical trials in ALS and served as a Chair of ALS Association Medical Advisory Board and Chair of ALS Center Certification Committee for ALS Association.  He received the Donald C. Mulder Award for achievement, leadership, and dedication in ALS from ALS Association in 1996, the Forbes H. Norris Award for Compassion and Love for Humanity in Research and Treatment in Patients with ALS from the International ALS Symposium and International ALS Alliance in 1998, Lou Gehrig Memorial Award from the MDA in 2000, and Diamond Award from the MDA Wings Over Wall Street in 2002.  He has published more than 200 articles in peer-reviewed journals, mostly in ALS, in addition to reviews, chapters, and books. He has been named one of the Best Doctors in America since 1996 and America’s Top Doctors for the past several years. One of his edited books, ALS: A Guide for Patients and Families, is currently in its 3rd edition.  For more than a decade, his research interests have expanded to PLS.