AKV9, Protein Aggregation Degrader
P. Hande Özdinler, Ph.D., Associate Professor of Neurology, Feinberg School of Medicine, Northwestern University (ALS and other upper motor neuron diseases)
William Klein, Ph.D., Professor of Neurobiology, Professor of Neurology, Northwestern University; co-Founder, Acumen Pharmaceuticals (Alzheimer’s disease)
Joseph R. Mazzulli, Ph.D., Professor of Neurology, Feinberg School of Medicine, Northwestern University (protein aggregation disorders, including age-related neurodegeneration, Parkinson’s disease, and Lewy body dementias)
Neuronal Nitric Oxide Synthase Inhibitors
William Klein, Ph.D., Professor of Neurobiology, Professor of Neurology, Northwestern University; co-Founder, Acumen Pharmaceuticals (Alzheimer’s disease)
Sun Yang, Ph.D., Associate Professor, Department of Pharmacy Practice, Chapman University School of Pharmacy (melanoma)
Ornithine Aminotransferase Inactivator
Dr. Wenan Qiang, M.D., Ph.D., Research Professor in the Department of Pathology, Feinberg School of Medicine and the Chemistry of Life Processes Institute, Northwestern University (xenograft, orthotropic, syngeneic, metastatic, and patient-derived tumor models)
Dali Liu, Ph.D., Professor of Chemistry, Loyola University, Chicago (protein crystallography of our inactivators bound to OAT)